Miyamoto's name comes from the famous Japanese samurai, Musashi Miyamoto. Jessie's name is Musashi, so her mother's name is Miyamoto. In fanfiction, Miyamoto's English name is sometimes given as Melissa. It's highly unlikely that this CD Drama will ever be dubbed into English, much like Mondo's "It's a White Tomorrow: Rocket Gang!" CD Drama. Here's some info on the Mewtwo CD Drama:
When Mewtwo was first created (before he destroyed the lab), he was in a glass cylinder, where he met Dr. Fuji's cloned daughter. Dr. Fuji, the scientist responsible for Mewtwo's creation, had lost his only daughter (whose name was Ai, meaning love) in a car accident. He then cloned many copies of his daughter... whenever one would expire, he'd just pop out another clone. His wife left him because of this. Mewtwo's only friend in the lab was one of the "Ai-Two"s.. a clone of the daughter. When she 'was no more', Mewtwo watched in horror as another was just made. It was like his friend was expendable. No wonder Mewtwo's got issues!
A slightly different version of this story (without Madam Boss or Miyamoto) appears as a Special Feature on the Mewtwo Returns DVD. The sequence with Ai-Two (renamed Amber-Two) and little Mewtwo playing with the other Starter Pokemon clones is shown. (Perhaps later, when Mewtwo rebuilt the lab on New Island, he used the DNA of these same Starter Pokemon to create his super-powered clones of Blastoise, Venusaur, and Charizard?) Squirtle-Two, Charmander-Two, and Bulbasaur-Two fade away, and Amber soon follows. The last words she speaks to Mewtwo are "Life is wonderful..." The genetic Mew-clone does survive, but he is extremely upset. The scientists administer chemicals to erase his memory, not wanting him to become agitated, and he calms down. The only thing he remembers from the encounter are Amber's last words. "Life is wonderful... but why?" he wonders, all other memories of the event deleted from his mind.